Borna virus has a wide host rangein vivo and a comparatively wide spectrum of cell cultures susceptible to it (Table 5.1). Borna antigen can be detected through immunofluorescence (2) in the nuclei of infected cells 2 or 3 days after inoculation (Fig. 5.1). On the third or fourth day, fluorescence is noted also in the cytoplasm (Fig. 5.2). The virus spreads slowly from cell to cell and thus.
Research over the past 100 years has established that the aetiological agent, Borna disease virus (BDV), is an unsegmented, single- and negative-stranded, enveloped ribonucleic acid (RNA) virus which represents the family Bornaviridae in the order Mononegavirales. The virus exists world-wide in horses, sheep, cattle, cats, dogs and ostriches. The infection can be fatal, but the majority of.
Human Borna disease virus-infection and its therapy in affective disorders This paper reports on a number of studies by the authors and colleagues examining the antiviral effects of amantadine in BDV-infected human patients with affective disorders. In one small study with 25 subjects, the authors delivered amantadine to two groups of BDV-infected patients: those with a diagnosis of bipolar.
The paper uses interviews and observational data gathered among a group of UK scientists and civil servants responsible for managing a study examining the possible transmission to humans of Borna disease virus (BDV), a disease primarily of farm animals. From a science and technology studies perspective, the paper examines the social processes.
Research output: Contribution to. In the two consecutive papers, we used the neonatal Borna disease virus (BDV) infection rat model of neurodevelopmental damage to evaluate brain pathology, monoamine alterations, behavioral deficits, and responses to pharmacological treatments in two inbred rat strains, Lewis and Fisher344. The first paper reports that despite comparable virus replication.
Mammalian Bornavirus (BoDV-1) typically causes a fatal neurologic disorder in horses and sheep, and was recently shown to cause fatal encephalitis in humans with and without transplant reception. It has been suggested that BoDV-1 enters the central nervous system (CNS) via the olfactory pathway. However, (I) susceptible cell types that replicate the virus for successful spread, and (II) the.
Borna disease virus, a newly classified nonsegmented negative-strand RNA virus with international distribution, infects a broad range of warm-blooded animals from birds to primates. Infection causes movement and behavioral disturbances reminiscent of some neuropsychiatric syndromes. The virus has not been clearly linked to any human disease; however, an association between infection with the.
To the Editor. Czygan et al. (1) reported the detection of Borna disease virus (BDV) nucleic acid in 3 cases of a rare form of hippocampal degeneration, whereas the brains of patients with other neuropsychiatric disorders tested negative for BDV. Chronic fatigue syndrome (CFS) is another, more frequently diagnosed neuropsychiatric disease that is associated with BDV infection.